# Why Losing Muscle With Age May Raise Your Cancer Risk

*Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Nature communications
- **Sample Size**: Fruit fly and mouse cancer models
- **Authors**: Goh KY, Lee WX, Gou Q, Choy SM, Ong SC, Gopal Krishnan PD, Wang H, Turqueza LRR, Tan QH, Chua K, Li S, Nishiyama J, Harmston N, Tang HW
- **Published**: 2026-04-27
- **Topics**: sarcopenia, cancer, exercise
- **DOI**: https://doi.org/10.1038/s41467-026-72410-y
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42045191/

## Summary

Gesunde Muskeln setzen winzige Pakete namens extrazelluläre Vesikel frei, die Tumorwachstum unterdrücken. Mit dem altersbedingten Muskelabbau (Sarkopenie) werden weniger dieser schützenden Pakete ausgeschüttet. Bei Fliegen und Mäusen wuchsen Tumoren dadurch leichter. Sport reaktivierte den Pfad, der diese Anti-Tumor-Vesikel produziert.

## Practical Takeaway

This study suggests maintaining muscle through exercise may support the body's natural anti-tumor signaling.

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_Canonical: https://longevity-cities.com/de/research/why-losing-muscle-with-age-may-raise-your-cancer-risk · Part of Longevity Cities · Updated 2026-04-27_