# GLP-1 agonists and cognition

1 paper in the library, strongest Moderate.

**Graded Moderate**: Post hoc analysis of a randomized trial in 2,970 adults aged 65 and over across 104 weeks, though the outcome was a predicted-risk protein score rather than dementia itself.

## Papers (1)

- [Semaglutide Slowed a Blood-Based Dementia Risk Score in Older Heart Patients](https://longevity-cities.com/en/research/semaglutide-slowed-a-blood-based-dementia-risk-score-in-older-heart-patients) · Moderate · n = 2970 · 2026 · Alzheimer's & dementia (Amsterdam, Netherlands)

## How this map is computed

A mark's size is the number of papers we hold on that pairing. It is a count, not a weighting by study design or sample size.

The fill shows the strongest grade in the cell. One Strong paper among four Preliminary ones still fills it dark, so open the cell to see the rest.

Grades and verdicts are assigned by a named person, never by counting.

An empty cell is a finding: nobody in our library has run that trial yet.

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_Canonical: https://longevity-cities.com/en/evidence/glp-1/cognition · Part of Longevity Cities_