# A Single Protein's Decline in Immune Cells May Drive Body-Wide Aging

*Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Cell death and differentiation
- **Sample Size**: Mice plus lab cell experiments
- **Authors**: Lv N, Tang Y, Zhang W, Zhang Q, Zhang H, Gao H, Cui S, Krasny S, Shi L
- **Published**: 2026-07-16
- **Topics**: immune aging, inflammation, senescence
- **DOI**: https://doi.org/10.1038/s41418-026-01823-5
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42463581/

## Summary

In mice, a protein called Lamtor5 drops with age and lets immune cells called macrophages go into a worn-out, inflammatory state. When scientists put these aged immune cells into young mice, the young mice aged faster. Clearing out the old cells or blocking the harmful pathway calmed inflammation and helped tissues work better. This adds to the idea that aging immune cells fuel the low-grade inflammation behind many age-related problems.

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_Canonical: https://longevity-cities.com/en/research/a-single-protein-s-decline-in-immune-cells-may-drive-body-wide-aging · Part of Longevity Cities · Updated 2026-07-16_