# Low B Vitamins May Be a Hidden Driver of Age-Related Muscle Loss

*Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Journal of Yeungnam medical science
- **Sample Size**: N/A
- **Authors**: Kwon K, Lee S, Kwon J, Kim SW
- **Published**: 2026-08-03
- **Topics**: sarcopenia, B vitamins, muscle
- **DOI**: https://doi.org/10.12701/jyms.2026.43.51
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42544408/

## Summary

Muscle loss with age is usually blamed on too little protein or exercise, but B vitamins may play a role too. This review argues that low B6, folate and B12 can starve muscle cells of energy, raise inflammation, and shift signals toward muscle breakdown. Evidence for the other B vitamins is still thin. Nobody has proven yet that taking B vitamins protects muscle, so trials are needed.

## Practical Takeaway

This review suggests B vitamin status is worth discussing with a doctor if muscle strength is declining.

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_Canonical: https://longevity-cities.com/en/research/low-b-vitamins-may-be-a-hidden-driver-of-age-related-muscle-loss · Part of Longevity Cities · Updated 2026-08-03_