# Probiotics Plus Vitamin D Linked to Remission in a Painful Mouth Condition

_Evidence Level: Preliminary · Zanetta P et al., International journal of molecular sciences, DOI 10.3390/ijms27156707_

*Effects of Probiotics and Vitamin D Deficiency Correction on Clinical, Inflammatory, Metabolic, and Microbiota Profiles in Older Adults with Oral Lichen Planus: A Multi-Omics Study.*

- **Evidence Level**: Preliminary
- **Why this grade**: Sixteen-week single-arm study in 25 older adults with oral lichen planus, with no control group and vitamin D given only to deficient patients.
- **Facts**: Funding: University of Piemonte Orientale Amedeo Avogadro; European Union
- **Publication Types**: Journal Article
- **Journal**: International journal of molecular sciences
- **Sample Size**: 25 adults with oral lichen planus, median age 68
- **Authors**: Zanetta P, Calgaro M, Mellai M, Vignoli A, Marotta M, Vitulo N, Tenori L, Manfredi M, Barberis E, Migliario M, Armari M, Caneparo V, Squarzanti DF, Allesina M, Amoruso A, Pane M, Azzimonti B
- **Graded and published**: 2026-07-27
- **Last edited**: 2026-09-17
- **Topics**: probiotics, vitamin D, oral health
- **DOI**: https://doi.org/10.3390/ijms27156707
- **Free full text**: https://pmc.ncbi.nlm.nih.gov/articles/PMC13467221/
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42589365/

## Summary

Oral lichen planus is a chronic inflammatory condition in the mouth that is hard to treat and carries a small cancer risk. In 25 mostly older adults, 16 weeks of a three-strain probiotic blend, plus vitamin D3 for those who were deficient, came with fewer and smaller lesions. About three quarters were rated as in remission, and gut and saliva chemistry shifted too. There was no control group, so we cannot say the supplements alone caused the improvement.

## Practical Takeaway

This study suggests probiotics and vitamin D deserve testing for oral inflammation in larger controlled trials.

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_Canonical: https://longevity-germany.com/en/research/probiotics-plus-vitamin-d-linked-to-remission-in-a-painful-mouth-condition · Part of Longevity Cities · Updated 2026-09-17_