# Which Interventions Actually Turn Back Your Epigenetic Clock in Humans

*Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Review
- **Journal**: Frontiers in genetics
- **Sample Size**: N/A (review of 41 human studies)
- **Authors**: Johnson AA, Sinclair DA
- **Published**: 2026-05-29
- **Topics**: epigenetic clock, longevity, supplements
- **DOI**: https://doi.org/10.3389/fgene.2026.1836446
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42294499/

## Summary

Researchers gathered 41 human studies to see what really lowers your epigenetic age, the newer clocks tied to death risk. Exercise, a plant-rich diet, semaglutide, calorie cutting, omega-3s, and a multivitamin showed promise. But popular bets like nicotinamide riboside, rapamycin, and senolytics showed no measurable effect.

## Practical Takeaway

This review suggests exercise, omega-3s, and a plant-rich diet may lower epigenetic age in people.

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