Creatine and cognition
Not yet reviewed by a human. 2 papers are in the library.
Graded Moderate · Double-blind randomized trial in 64 sedentary adults aged 45 to 65 over 12 weeks, though the sample was small and the cognitive and biomarker findings were exploratory.
Papers 2
- Creatine Built Muscle in Midlife Adults Even Without a Single WorkoutModeraten = 642026Journal of the International Society of Sports NutritionAdults aged 45 to 65 took 10 grams of creatine daily for 12 weeks, either alone or alongside exercise and a weight-loss diet. Even the group that didn't train gained lean tissue, strength, and muscular endurance, plus small improvements in blood lipids, HbA1c, and some memory tests. Those who also exercised and dieted lost more body fat on top of that. The cognitive and blood marker results are early and the researchers call them exploratory.
- Creatine and Dementia: Big Hype, Surprisingly Thin Human EvidencePreliminaryn = 202026Ageing research reviewsCreatine is popular for muscle and increasingly for the brain, so researchers combed through everything published on creatine and dementia. They found just six studies, mostly in animals and cells, and zero controlled clinical trials. One small human pilot with 20 people taking 20g a day for 8 weeks raised brain creatine by 11% and was linked to better flexible thinking. Results were mixed though: one rodent study showed worse spatial memory, and effects seemed to differ between males and females.
How this map is computed
A mark's size is the number of papers we hold on that pairing. It is a count, not a weighting by study design or sample size.
The fill shows the strongest grade in the cell. One Strong paper among four Preliminary ones still fills it dark, so open the cell to see the rest.
Grades and verdicts are assigned by a named person, never by counting.
An empty cell is a finding: nobody in our library has run that trial yet.