Omega-3 and cognition
2 papers in the library, strongest Strong.
Graded Strong · Twelve-month randomized, double-blind, placebo-controlled trial in 360 older adults with MCI, with near-complete follow-up of 355 participants, though still a single trial awaiting replication.
Papers 2
- Vitamin D3 Plus DHA Beat Either Alone for Memory in Older Adults With MCIStrongn = 3602026NutrientsOlder adults with mild cognitive impairment took vitamin D3, DHA (an omega-3 fat), both, or a placebo for a year. All three supplement groups scored better on IQ-based cognitive tests than placebo, but the combination did best. Blood markers of a fiery type of cell death called pyroptosis also dropped most in the combined group, and one of them, GSDMD, seemed to explain part of the mental gains.
- High-Dose DHA Reaches the Brain but Didn't Boost Memory in 2 YearsStrongn = 3652026EBioMedicineOmega-3 DHA is a popular pick for brain health, especially for people at risk of dementia. This two-year trial gave older adults with low omega-3 intake high-dose DHA. The DHA clearly made it into their brain fluid, even in those carrying the high-risk APOE ε4 gene. But there was no difference in memory, thinking, or brain size compared to placebo.
How this map is computed
A mark's size is the number of papers we hold on that pairing. It is a count, not a weighting by study design or sample size.
The fill shows the strongest grade in the cell. One Strong paper among four Preliminary ones still fills it dark, so open the cell to see the rest.
Grades and verdicts are assigned by a named person, never by counting.
An empty cell is a finding: nobody in our library has run that trial yet.