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Metabolism

Metabolic syndrome

DEMetabolisches Syndrom

Metabolic syndrome is a cluster of linked cardiometabolic risk factors that sharply raise your risk of type 2 diabetes, heart disease, and early death. The most-used criteria (from the IDF and the harmonized 2009 IDF/AHA/NHLBI statement) require three or more of five components. Those are: a large waist (with ethnicity-specific thresholds), high fasting triglycerides (≥150 mg/dL), low HDL cholesterol (under 40 mg/dL in men, under 50 in women), high blood pressure (≥130/85 mmHg), and high fasting glucose (≥100 mg/dL). The central drivers are insulin resistance and belly fat. It affects over 30% of Western adults and rises with age. So it is a key target for both lifestyle and drug-based longevity interventions.

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Sources

  1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. (2005). Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulationdoi:10.1161/CIRCULATIONAHA.105.169404
  2. Alberti KG, Eckel RH, Grundy SM, et al. (2009). Harmonizing the metabolic syndrome: a joint interim statement of the IDF Task Force on Epidemiology and Prevention; NHLBI; AHA; WHF; IAS; and IASO. Circulationdoi:10.1161/CIRCULATIONAHA.109.192644

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