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Aging clocks

PhenoAge

PhenoAge is a composite measure of your biological age. Levine and colleagues developed it in 2018. The original version is blood-based. It blends nine clinical markers with your chronological age, calibrated against death risk. Those markers include albumin, creatinine, glucose, C-reactive protein, and white blood cell count. There is also a DNA-methylation version, called DNAm PhenoAge. It ports the score onto epigenetic data. PhenoAge predicts all-cause death and multimorbidity better than chronological age alone. It has been validated in several large cohorts. But its clinical use is still emerging.

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