A New Drug Combo May Protect Muscle During Ozempic-Style Weight Loss
Drugs like semaglutide help people lose weight but often shrink muscle too. In obese mice, adding an experimental compound called a 15-PGDH inhibitor helped muscles repair and regrow after injury, without canceling out the weight loss. This points to a possible way to keep muscle while on GLP-1 drugs.
Conflict of Interest Disclosure: One author consults for and holds patents licensed to Epirium Bio; another co-founded Merrifield Therapeutics.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
Topics
Related Studies
All researchFor Older Muscle Quality, Lifting Weights Beat Supplements and Cardio
Looking at dozens of trials in adults over 60, resistance training was the only thing that clearly improved muscle quality (strength…
Semaglutide Slowed a Blood-Based Dementia Risk Score in Older Heart Patients
Older adults with excess weight and heart disease but no diabetes took semaglutide or a placebo for two years.
Low B Vitamins May Be a Hidden Driver of Age-Related Muscle Loss
Muscle loss with age is usually blamed on too little protein or exercise, but B vitamins may play a role too.