A New Drug Combo May Protect Muscle During Ozempic-Style Weight Loss
Based on: 15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss.
Drugs like semaglutide help people lose weight but often shrink muscle too. In obese mice, adding an experimental compound called a 15-PGDH inhibitor helped muscles repair and regrow after injury, without canceling out the weight loss. This points to a possible way to keep muscle while on GLP-1 drugs.
Original Paper
Nalbandian M, Lone J, Le Moal E, Kim I, Jeuris K, Li YK, Kraft P, Zhao M, Koleckar K, Zhang Z, Svensson KJ, Blau HM
Conflict of Interest Disclosure: One author consults for and holds patents licensed to Epirium Bio; another co-founded Merrifield Therapeutics.
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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.