Eight Hyped Compounds Failed to Extend Lifespan in a Major Mouse Study
This study suggests that dose and timing matter enormously, and early lifespan results in mice often don't hold up.
The NIA's Interventions Testing Program tested eight compounds across three lab sites in genetically diverse mice. None extended lifespan. That includes astaxanthin, alpha-ketoglutarate, pioglitazone, atorvastatin-telmisartan, and others with prior promising results. Some compounds previously shown to work at different doses or start ages didn't replicate under new conditions. Two drugs actually shortened lifespan in female mice.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
Related Studies
All researchWhy Your Fitness Level Predicts How Long You'll Live Better Than Step Counts
This review of the evidence says being physically active and, even more so, being fit is strongly tied to living longer.
Low Muscle Mass Linked to 42% Higher Death Risk in Adults
People with less fat-free mass, which is mostly muscle, had a much higher chance of dying early.
Higher Vitamin C, D, and Carotenoids Linked to Living Longer
U.S. adults with higher blood levels of vitamin C, vitamin D, beta-carotene, and lycopene were less likely to die during the study.