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Journal ArticleReviewAgeing research reviews·Graded and published ·Last edited

How Cutting Calories May Rejuvenate the Body's Aging Stem Cells

Graded Moderate — narrative review with no new data, synthesizing mechanistic and largely animal evidence on how caloric restriction affects aged stem cells, with little direct testing in people.

Design
Review
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Key Insight

This review suggests caloric restriction may help refresh aging stem cells, mostly based on animal work.


Our stem cells repair tissue, but they slow down as we age. This review looks at how eating less, known as caloric restriction, can refresh tired stem cells in blood, gut, brain, and muscle. Much of the effect runs through a nutrient-sensing pathway called mTOR, the same one that drugs like rapamycin target.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.