Metformin Added Nothing to Diet and Exercise for Older Adults' Strength
This study suggests structured exercise and diet drive physical function gains, not metformin.
Metformin has a big fan club in longevity circles, but this trial puts a dent in the hype. Older adults with obesity, aged 65 to 85, did six months of serious diet and exercise coaching. Adding metformin on top gave zero extra improvement in physical function compared to a placebo. The lifestyle program itself was what moved the needle.
Conflict of Interest Disclosure: None declared; funded by the US Department of Veterans Affairs.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
Related Studies
All researchFor Older Muscle Quality, Lifting Weights Beat Supplements and Cardio
Looking at dozens of trials in adults over 60, resistance training was the only thing that clearly improved muscle quality (strength…
Exercise Helps Aging Brains Most If You're Older or Mostly Sedentary
Middle-aged and older adults who moved more had healthier-looking brain wiring on MRI scans, but the benefit wasn't the same for everyone.
A 9-Year Mailed Exercise Program Barely Moved the Needle in Older Women
Nearly 50,000 women aged 66 to 99 were randomly assigned to a long-running, remotely delivered program that encouraged more movement and…
