Spermidine Cut Dry Mouth Nearly in Half for Cancer Patients After Radiation
Graded Moderate — randomized double-blind trial in about 58 head and neck cancer patients followed for 3 months, though it was a small proof-of-concept study not yet repeated.
- Design
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- Participants
- 58
- Duration
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- Funding
- The authors report no conflicts of interest.
This study suggests spermidine may help protect salivary glands during head and neck radiation.
Radiation for head and neck cancer often wrecks the salivary glands, leaving people with a miserably dry mouth. In a small human trial, people taking spermidine during radiation had far fewer cases of dry mouth at 3 months, 48% versus 79% on placebo. Their saliva flow and quality of life improved, with no serious side effects. Mouse and lab work backed up how the supplement protects gland cells.
Conflict of Interest Disclosure: The authors report no conflicts of interest.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.